Laurence J Miller Selected Research

Cholecystokinin Receptors (Cholecystokinin Receptor)

1/2021	Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol.
1/2021	Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics.
1/2019	Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor.
9/2015	Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function.
5/2015	Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.
3/2013	Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: use of cell lines with elevated cholesterol.
5/2005	Analysis of the cellular and molecular mechanisms of trophic action of a misspliced form of the type B cholecystokinin receptor present in colon and pancreatic cancer.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Laurence J Miller Research Topics

Disease

18	Neoplasms (Cancer) 01/2019 - 01/2002
12	Obesity 01/2021 - 05/2015
8	Type 2 Diabetes Mellitus (MODY) 01/2018 - 12/2009
7	Pancreatic Neoplasms (Pancreatic Cancer) 12/2011 - 02/2002
4	Hypercholesterolemia 01/2021 - 03/2013
3	Weight Loss (Weight Reduction) 01/2021 - 02/2013
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2016 - 01/2012
3	Diabetes Mellitus 02/2012 - 06/2008
3	Adenocarcinoma 12/2011 - 09/2002
3	Carcinoma (Carcinomatosis) 04/2010 - 02/2002
2	Gallstones (Gallstone) 03/2020 - 09/2015
2	Chronic Disease (Chronic Diseases) 01/2020 - 01/2017
2	Carcinogenesis 01/2019 - 04/2006
2	Pain (Aches) 11/2017 - 01/2009
2	Cholangiocarcinoma 04/2008 - 12/2006
2	Chronic Pancreatitis 12/2007 - 09/2007
2	Gastrinoma 09/2002 - 02/2002
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2020
1	Dyspepsia (Indigestion) 01/2020
1	Metabolic Diseases (Metabolic Disease) 11/2018
1	Cholelithiasis 08/2017
1	Osteoporosis 01/2017
1	Amyloid Plaque 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 01/2017
1	Shock 06/2014
1	Mason-Type Diabetes 06/2013
1	Insulin Resistance 02/2013
1	Insulinoma 04/2010
1	Lung Neoplasms (Lung Cancer) 04/2008
1	Inflammation (Inflammations) 04/2008
1	Carcinoid Tumor (Carcinoid) 04/2008
1	Abdominal Pain (Pain, Abdominal) 12/2007
1	Bile Duct Neoplasms (Bile Duct Cancer) 09/2007
1	Hepatocellular Carcinoma (Hepatoma) 12/2006
1	Liver Neoplasms (Liver Cancer) 12/2006

Drug/Important Bio-Agent (IBA)

10	Cholecystokinin (Pancreozymin)IBA 01/2021 - 02/2002
10	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2018 - 06/2008
9	Secretin FDA Link 01/2020 - 02/2002
9	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020 - 12/2009
7	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 01/2021 - 05/2005
7	CholesterolIBA 01/2021 - 01/2012
7	Hormones (Hormone)IBA 03/2020 - 01/2002
7	secretin receptorIBA 01/2020 - 02/2002
6	Messenger RNA (mRNA)IBA 01/2019 - 02/2002
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2002
6	Peptides (Polypeptides)IBA 01/2017 - 05/2005
4	Glucose (Dextrose)FDA LinkGeneric 11/2017 - 02/2013
4	GTP-Binding Proteins (G-Protein)IBA 06/2014 - 02/2002
3	Peptide Hormones (Polypeptide Hormones)IBA 01/2021 - 10/2016
3	EnzymesIBA 01/2020 - 09/2007
3	Glucagon-Like Peptide-1 ReceptorIBA 10/2016 - 02/2012
3	Pharmaceutical PreparationsIBA 05/2015 - 12/2009
3	LigandsIBA 06/2014 - 08/2010
3	Insulin (Novolin)FDA Link 08/2013 - 02/2012
3	IncretinsIBA 08/2013 - 05/2011
3	RNA Precursors (Precursor, mRNA)IBA 08/2009 - 04/2006
3	Peptide Receptors (Peptide Receptor)IBA 08/2009 - 04/2008
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 08/2009
2	LipidsIBA 01/2019 - 01/2005
2	Amino Acids FDA Link 01/2017 - 10/2016
2	RNA (Ribonucleic Acid)IBA 12/2011 - 02/2002
2	Arginine (L-Arginine)FDA Link 03/2007 - 04/2006
2	Protein Kinases (Protein Kinase)IBA 03/2007 - 04/2006
2	Serine (L-Serine)FDA Link 03/2007 - 04/2006
2	Protein Isoforms (Isoforms)IBA 10/2005 - 01/2002
2	GastrinsIBA 02/2002 - 02/2002
1	sacubitrilIBA 01/2020
1	Neprilysin (Neutral Endopeptidase)IBA 01/2020
1	farnesyl pyrophosphate (farnesyl diphosphate)IBA 01/2019
1	TransferasesIBA 01/2019
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 01/2017
1	gamma-sitosterol (beta-sitosterol)IBA 12/2016
1	Glucagon-Like Peptides (Enteroglucagon)IBA 10/2016
1	Drug CombinationsIBA 01/2016
1	Chenodeoxycholic Acid (Chenix)FDA Link 09/2015
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 09/2015
1	Drinking WaterIBA 06/2014
1	Factor XI (Plasma Thromboplastin Antecedent)IBA 06/2013
1	Exenatide (Byetta)FDA Link 01/2012
1	matrigelIBA 12/2011
1	Small Interfering RNA (siRNA)IBA 12/2011
1	Matrix Metalloproteinases (MMPs)IBA 12/2011
1	sulfhydryl oxidaseIBA 12/2011
1	somatotropin releasing hormone receptorIBA 08/2009
1	Cholecystokinin A ReceptorIBA 04/2009
1	Opioid Analgesics (Opioids)IBA 01/2009
1	Somatostatin Receptors (Somatostatin Receptor)IBA 04/2008
1	ChromiumIBA 12/2007
1	SeleniumIBA 12/2007
1	SmokeIBA 12/2007
1	Heavy MetalsIBA 12/2007
1	MolybdenumIBA 12/2007
1	MetalsIBA 12/2007
1	ImmunosorbentsIBA 09/2007
1	Phosphotransferases (Kinase)IBA 03/2007
1	Mitogen-Activated Protein KinasesIBA 03/2007
1	Cisplatin (Platino)FDA LinkGeneric 04/2006

Therapy/Procedure

5	Therapeutics 02/2013 - 10/2005
1	Oral Administration 12/2016